| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Trypanothione reductase |
|---|
| Ligand | BDBM50087155 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_211810 |
|---|
| IC50 | 1100±n/a nM |
|---|
| Citation |  Salmon-Chemin, L; Lemaire, A; De Freitas, S; Deprez, B; Sergheraert, C; Davioud-Charvet, E Parallel synthesis of a library of 1,4-naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi. Bioorg Med Chem Lett10:631-5 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Trypanothione reductase |
|---|
| Name: | Trypanothione reductase |
|---|
| Synonyms: | N(1),N(8)-bis(glutathionyl)spermidine reductase | TPR | TR | TYTR_TRYCR |
|---|
| Type: | Homodimer; oxidoreductase |
|---|
| Mol. Mass.: | 53868.26 |
|---|
| Organism: | Trypanosoma cruzi |
|---|
| Description: | n/a |
|---|
| Residue: | 492 |
|---|
| Sequence: | MMSKIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVP
KKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKKLIAVKDEAVLNINKSYEEMFRDTEG
LEFFLGWGSLESKNVVNVRESADPASAVKERLETENILLASGSWPHMPNIPGIEHCISSN
EAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELT
KQLTANGIQILTKENPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNA
GVMIKNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGTNPRKTDHT
RVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHNISGSKYKTFVAKIITNHS
DGTVLGVHLLGDNAPEIIQGVGICLKLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVK
GEKMEKPSEASL
|
|
|
|---|
| BDBM50087155 |
|---|
| n/a |
|---|
| Name | BDBM50087155 |
|---|
| Synonyms: | 5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-pentanoic acid (3-dibutylamino-propyl)-amide | CHEMBL155801 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H40N2O3 |
|---|
| Mol. Mass. | 440.6181 |
|---|
| SMILES | CCCCN(CCCC)CCCNC(=O)CCC=Cc1c(C)c(O)c2ccccc2c1O |w:17.16| |
|---|
| Structure | 
|
|---|
Search and Browse
