| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 7 |
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| Ligand | BDBM50531687 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1920591 (CHEMBL4423436) |
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| IC50 | 347±n/a nM |
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| Citation |  Reed, CW; Yohn, SE; Washecheck, JP; Roenfanz, HF; Quitalig, MC; Luscombe, VB; Jenkins, MT; Rodriguez, AL; Engers, DW; Blobaum, AL; Conn, PJ; Niswender, CM; Lindsley, CW Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu J Med Chem62:1690-1695 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 7 |
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| Name: | Metabotropic glutamate receptor 7 |
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| Synonyms: | GRM7_RAT | Gprc1g | Grm7 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 7 (mGlu7) | Mglur7 | mGlu7 |
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| Type: | Enzyme |
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| Mol. Mass.: | 102244.48 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P35400 |
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| Residue: | 915 |
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| Sequence: | MVQLGKLLRVLTLMKFPCCVLEVLLCVLAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK
GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL
TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA
STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ
ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK
RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR
NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH
ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRHVNFNGSAGTPVMFNKNGDAPGRYDIF
QYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPSSVCTLPCKPGQRKKTQKGTP
CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQNIPIIKLEWHSPWAVIPVFLAML
GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV
FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW
FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV
PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML
YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS
PAAKKKYVSYNNLVI
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| BDBM50531687 |
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| n/a |
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| Name | BDBM50531687 |
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| Synonyms: | CHEMBL4445682 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H19F3N4O4 |
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| Mol. Mass. | 448.3952 |
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| SMILES | COc1cc(ccc1OCC1CC1)C(=O)Nc1cc(OC(F)(F)F)ccc1-n1cncn1 |
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| Structure | 
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