| Reaction Details |
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 | Report a problem with these data |
| Target | M-phase inducer phosphatase 2 |
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| Ligand | BDBM50087205 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_49039 |
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| IC50 | 15000±n/a nM |
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| Citation |  Fritzen, EL; Brightwell, AS; Erickson, LA; Romero, DL The solid phase synthesis of tetrahydroisoquinolines having cdc25B inhibitory activity. Bioorg Med Chem Lett10:649-52 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| M-phase inducer phosphatase 2 |
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| Name: | M-phase inducer phosphatase 2 |
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| Synonyms: | CDC25B | CDC25HU2 | Dual specificity phosphatase (CDC25B) | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 (CDC25B) | MPIP2_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 64985.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 580 |
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| Sequence: | MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMH
DLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMD
PHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEA
GSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPD
RKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKT
LEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQ
QEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETM
VALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKR
VILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQ
DYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
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| BDBM50087205 |
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| n/a |
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| Name | BDBM50087205 |
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| Synonyms: | (S)-7-(2,4-Dichloro-benzyloxy)-6,8-diiodo-2-[(E)-3-(3-trifluoromethyl-phenyl)-acryloyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid | CHEMBL158979 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H18Cl2F3I2NO4 |
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| Mol. Mass. | 802.146 |
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| SMILES | OC(=O)[C@@H]1Cc2cc(I)c(OCc3ccc(Cl)cc3Cl)c(I)c2CN1C(=O)\C=C\c1cccc(c1)C(F)(F)F |
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| Structure | 
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