Reaction Details |
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Target | Alpha-1A adrenergic receptor |
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Ligand | BDBM50087476 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_34033 (CHEMBL646286) |
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Ki | 0.39±n/a nM |
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Citation | Meyer, MD; Altenbach, RJ; Basha, FZ; Carroll, WA; Condon, S; Elmore, SW; Kerwin, JF; Sippy, KB; Tietje, K; Wendt, MD; Hancock, AA; Brune, ME; Buckner, SA; Drizin, I Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH). J Med Chem43:1586-603 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-1A adrenergic receptor |
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Name: | Alpha-1A adrenergic receptor |
Synonyms: | ADA1A_RAT | Adra1a | Adra1c | Alpha-1 adrenoreceptor | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor | adrenergic Alpha1A |
Type: | Protein |
Mol. Mass.: | 51620.15 |
Organism: | Rattus norvegicus (Rat) |
Description: | P43140 |
Residue: | 466 |
Sequence: | MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
VPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTL
HPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACT
TARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
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BDBM50087476 |
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n/a |
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Name | BDBM50087476 |
Synonyms: | 7-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-2,3-dimethyl-5H-9-thia-1,4,5,7-tetraaza-fluorene-6,8-dione | CHEMBL290243 |
Type | Small organic molecule |
Emp. Form. | C25H27N5O3S |
Mol. Mass. | 477.579 |
SMILES | COc1cccc2[C@@H]3CN(CCn4c(=O)[nH]c5c6nc(C)c(C)nc6sc5c4=O)C[C@@H]3CCc12 |
Structure |
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