Ki Summary

Reaction Details

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Target

Alpha-1B adrenergic receptor

Ligand

BDBM50087485

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_34312 (CHEMBL648097)

4.63±n/a nM

Citation

Meyer, MD; Altenbach, RJ; Basha, FZ; Carroll, WA; Condon, S; Elmore, SW; Kerwin, JF; Sippy, KB; Tietje, K; Wendt, MD; Hancock, AA; Brune, ME; Buckner, SA; Drizin, I Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH). J Med Chem43:1586-603 (2000) [PubMed]

More Info.:

Get all data from this article, Assay Method

Alpha-1B adrenergic receptor

Name:

Alpha-1B adrenergic receptor

Synonyms:

ADA1B_MESAU | ADRA1B | Adrenergic receptor alpha | Alpha-1b adrenergic receptor | adrenergic Alpha1B

Type:

Enzyme Catalytic Domain

Mol. Mass.:

56514.13

Organism:

C.H.O.

Description:

adrenergic Alpha1B ADRA1B C.H.O.::P18841

Residue:

515

Sequence:

MNPDLDTGHNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAI
VGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFM
RILGCQCRSGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLP
SASPSPGYLGRGAQPPLELCAYPEWKSGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESP
GTEGDASNGGCDATTDLANGQPGFKSNMPLAPGHF

BDBM50087485

n/a

Name

BDBM50087485

Synonyms:

2-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-4H-9-thia-2,4,6-triaza-fluorene-1,3-dione | A-131701 | CHEMBL287965

Type

Small organic molecule

Emp. Form.

C24H24N4O3S

Mol. Mass.

448.537

SMILES

COc1cccc2[C@@H]3CN(CCn4c(=O)[nH]c5c6cnccc6sc5c4=O)C[C@@H]3CCc12

Structure