| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-1B adrenergic receptor |
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| Ligand | BDBM50087470 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_34312 (CHEMBL648097) |
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| Ki | 1.7±n/a nM |
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| Citation |  Meyer, MD; Altenbach, RJ; Basha, FZ; Carroll, WA; Condon, S; Elmore, SW; Kerwin, JF; Sippy, KB; Tietje, K; Wendt, MD; Hancock, AA; Brune, ME; Buckner, SA; Drizin, I Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH). J Med Chem43:1586-603 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-1B adrenergic receptor |
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| Name: | Alpha-1B adrenergic receptor |
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| Synonyms: | ADA1B_MESAU | ADRA1B | Adrenergic receptor alpha | Alpha-1b adrenergic receptor | adrenergic Alpha1B |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 56514.13 |
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| Organism: | C.H.O. |
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| Description: | adrenergic Alpha1B ADRA1B C.H.O.::P18841 |
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| Residue: | 515 |
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| Sequence: | MNPDLDTGHNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAI
VGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFM
RILGCQCRSGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLP
SASPSPGYLGRGAQPPLELCAYPEWKSGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESP
GTEGDASNGGCDATTDLANGQPGFKSNMPLAPGHF
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| BDBM50087470 |
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| n/a |
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| Name | BDBM50087470 |
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| Synonyms: | 3-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindol-2-yl)-ethyl]-2,4-dioxo-1,2,3,4-tetrahydro-benzo[4,5]thieno[3,2-d]pyrimidine-8-carboxylic acid dimethylamide | CHEMBL290519 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H30N4O4S |
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| Mol. Mass. | 518.627 |
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| SMILES | COc1cccc2[C@@H]3CN(CCn4c(=O)[nH]c5c6cc(ccc6sc5c4=O)C(=O)N(C)C)C[C@@H]3CCc12 |
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| Structure | 
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