| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 4 |
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| Ligand | BDBM50531903 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1921368 (CHEMBL4424213) |
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| IC50 | 30000±n/a nM |
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| Citation |  Buldenko, VM; Trush, VV; Kobzar, OL; Drapailo, AB; Kalchenko, VI; Vovk, AI Calixarene-based phosphinic acids as inhibitors of protein tyrosine phosphatases. Bioorg Med Chem Lett29:797-801 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 4 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 4 |
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| Synonyms: | Megakaryocyte protein-tyrosine phosphatase (PTP-MEG2) | PTN4_HUMAN | PTPN4 | Protein-tyrosine phosphatase MEG1 | Tyrosine-protein phosphatase non-receptor type 4 (PTP-MEG1) |
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| Type: | Protein |
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| Mol. Mass.: | 105923.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 926 |
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| Sequence: | MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFK
HLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEE
YTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQ
PQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGG
ILIYKNRVRMNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKA
CVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPS
KPLARKLMDWEVVSRNSISDDRLETQSLPSRSPPGTPNHRNSTFTQEGTRLRPSSVGHLV
DHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPALPPKQSKKNSWNQIHY
SHSQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKM
PVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLL
VRPNAVYDVVEEKLENEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFD
QLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSII
NQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQ
VTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNK
RAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQ
YRFVCEAILKVYEEGFVKPLTTSTNK
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| BDBM50531903 |
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| n/a |
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| Name | BDBM50531903 |
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| Synonyms: | CHEMBL4530344 |
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| Type | Small organic molecule |
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| Emp. Form. | C56H52O12P4 |
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| Mol. Mass. | 1040.8999 |
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| SMILES | Oc1c2Cc3cc(CP(O)(=O)c4ccccc4)cc(Cc4cc(CP(O)(=O)c5ccccc5)cc(Cc5cc(CP(O)(=O)c6ccccc6)cc(Cc1cc(CP(O)(=O)c1ccccc1)c2)c5O)c4O)c3O |
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| Structure | 
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