Ki Summary

Reaction Details

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Target

Corticotropin-releasing factor receptor 1

Ligand

BDBM50087560

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_51284

3.5±n/a nM

Citation

Hsin, LW; Webster, EL; Chrousos, GP; Gold, PW; Eckelman, WC; Contoreggi, C; Rice, KC Synthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines: the development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor. Bioorg Med Chem Lett10:707-10 (2000) [PubMed]

More Info.:

Get all data from this article, Assay Method

Corticotropin-releasing factor receptor 1

Name:

Corticotropin-releasing factor receptor 1

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

47870.75

Organism:

Rattus norvegicus (rat)

Description:

Receptor binding assays were performed using rat cortex homogenate.

Residue:

415

Sequence:

MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEV
HQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPF
PIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA
STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS
VFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV

BDBM50087560

n/a

Name

BDBM50087560

Synonyms:

CHEMBL348967 | Ethyl-(4-fluoro-butyl)-[2,5,6-trimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine

Type

Small organic molecule

Emp. Form.

C24H33FN4

Mol. Mass.

396.544

SMILES

CCN(CCCCF)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C |(6.4,-1.55,;7.43,-2.71,;6.95,-4.16,;5.44,-4.49,;4.42,-3.34,;2.9,-3.66,;1.87,-2.52,;.37,-2.83,;7.98,-5.3,;7.5,-6.77,;8.54,-7.91,;8.07,-9.38,;10.04,-7.59,;10.5,-6.13,;11.92,-5.51,;11.76,-3.97,;12.9,-2.95,;10.25,-3.66,;9.62,-2.25,;9.48,-4.99,;13.25,-6.27,;13.25,-7.82,;11.9,-8.59,;14.58,-8.59,;15.92,-7.82,;17.24,-8.59,;15.92,-6.27,;14.58,-5.5,;14.56,-3.97,)|

Structure