| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysophosphatidylserine lipase ABHD12 |
|---|
| Ligand | BDBM50531972 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1921766 (CHEMBL4424611) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Granchi, C; Lapillo, M; Glasmacher, S; Bononi, G; Licari, C; Poli, G; El Boustani, M; Caligiuri, I; Rizzolio, F; Gertsch, J; Macchia, M; Minutolo, F; Tuccinardi, T; Chicca, A Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor. J Med Chem62:1932-1958 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysophosphatidylserine lipase ABHD12 |
|---|
| Name: | Lysophosphatidylserine lipase ABHD12 |
|---|
| Synonyms: | ABD12_HUMAN | ABHD12 | C20orf22 | Monoacylglycerol lipase ABHD12 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 45111.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1514755 |
|---|
| Residue: | 398 |
|---|
| Sequence: | MRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKR
ALGRRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQ
GLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQGKDQMWYEDALASSHPIILYLHGNAGT
RGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPV
YIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWF
FLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQ
FVPFHSDLGYRHKYIYKSPELPRILREFLGKSEPEHQH
|
|
|
|---|
| BDBM50531972 |
|---|
| n/a |
|---|
| Name | BDBM50531972 |
|---|
| Synonyms: | CHEMBL4536045 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H24FNO3 |
|---|
| Mol. Mass. | 369.4293 |
|---|
| SMILES | CC(C)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1cc(O)ccc1F |
|---|
| Structure | 
|
|---|
Search and Browse
