| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM50531972 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1921757 (CHEMBL4424602) |
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| Ki | 39±n/a nM |
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| Citation |  Granchi, C; Lapillo, M; Glasmacher, S; Bononi, G; Licari, C; Poli, G; El Boustani, M; Caligiuri, I; Rizzolio, F; Gertsch, J; Macchia, M; Minutolo, F; Tuccinardi, T; Chicca, A Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor. J Med Chem62:1932-1958 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33264.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
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| Residue: | 303 |
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| Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
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| BDBM50531972 |
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| n/a |
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| Name | BDBM50531972 |
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| Synonyms: | CHEMBL4536045 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24FNO3 |
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| Mol. Mass. | 369.4293 |
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| SMILES | CC(C)c1ccc(cc1)C(=O)C1CCN(CC1)C(=O)c1cc(O)ccc1F |
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| Structure | 
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