| Reaction Details |
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 | Report a problem with these data |
| Target | G protein-activated inward rectifier potassium channel 4 |
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| Ligand | BDBM50532042 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1921816 (CHEMBL4424661) |
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| EC50 | 850±n/a nM |
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| Citation |  Sharma, S; Kozek, KA; Abney, KK; Kumar, S; Gautam, N; Alnouti, Y; David Weaver, C; Hopkins, CR Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators. Bioorg Med Chem Lett29:791-796 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G protein-activated inward rectifier potassium channel 4 |
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| Name: | G protein-activated inward rectifier potassium channel 4 |
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| Synonyms: | CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47658.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107914 |
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| Residue: | 419 |
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| Sequence: | MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKC
NVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDH
VGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNA
FMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIK
SRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFE
VVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTP
SCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
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| BDBM50532042 |
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| n/a |
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| Name | BDBM50532042 |
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| Synonyms: | CHEMBL4518000 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22F3N7O |
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| Mol. Mass. | 433.4302 |
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| SMILES | Cc1cc(NC(=O)Cn2nnc(n2)-c2cccc(c2)C(F)(F)F)n(n1)C1CCCCC1 |
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| Structure | 
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