Reaction Details |
| Report a problem with these data |
Target | G protein-activated inward rectifier potassium channel 4 |
---|
Ligand | BDBM50532027 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1921816 (CHEMBL4424661) |
---|
EC50 | 848±n/a nM |
---|
Citation | Sharma, S; Kozek, KA; Abney, KK; Kumar, S; Gautam, N; Alnouti, Y; David Weaver, C; Hopkins, CR Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators. Bioorg Med Chem Lett29:791-796 (2019) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
G protein-activated inward rectifier potassium channel 4 |
---|
Name: | G protein-activated inward rectifier potassium channel 4 |
Synonyms: | CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5 |
Type: | PROTEIN |
Mol. Mass.: | 47658.06 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_107914 |
Residue: | 419 |
Sequence: | MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKC
NVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDH
VGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNA
FMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIK
SRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFE
VVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTP
SCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
|
|
|
BDBM50532027 |
---|
n/a |
---|
Name | BDBM50532027 |
Synonyms: | CHEMBL4529103 |
Type | Small organic molecule |
Emp. Form. | C20H19N7O |
Mol. Mass. | 373.4112 |
SMILES | Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(Cc2ccccc2)n1 |
Structure |
|