| Reaction Details |
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 | Report a problem with these data |
| Target | G protein-activated inward rectifier potassium channel 1 |
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| Ligand | BDBM50532040 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1921814 (CHEMBL4424659) |
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| EC50 | 187±n/a nM |
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| Citation |  Sharma, S; Kozek, KA; Abney, KK; Kumar, S; Gautam, N; Alnouti, Y; David Weaver, C; Hopkins, CR Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators. Bioorg Med Chem Lett29:791-796 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| G protein-activated inward rectifier potassium channel 1 |
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| Name: | G protein-activated inward rectifier potassium channel 1 |
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| Synonyms: | GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56610.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107915 |
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| Residue: | 501 |
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| Sequence: | MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL
GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY
TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM
FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPE
GEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILE
GIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKE
QEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMS
STTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGG
AARMEGNLPAKLRKMNSDRFT
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| BDBM50532040 |
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| n/a |
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| Name | BDBM50532040 |
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| Synonyms: | CHEMBL4522066 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22FN7O |
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| Mol. Mass. | 383.4227 |
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| SMILES | Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2F)n(n1)C1CCCCC1 |
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| Structure | 
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