| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2B |
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| Ligand | BDBM50301297 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1923999 (CHEMBL4426955) |
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| EC50 | 360±n/a nM |
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| Citation |  Green, MP; McMurray, G; Storer, RI Selective 5-HT2C receptor agonists: Design and synthesis of pyridazine-fused azepines. Bioorg Med Chem Lett26:4117-21 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2B |
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| Name: | 5-hydroxytryptamine receptor 2B |
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| Synonyms: | 5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 54312.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells. |
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| Residue: | 481 |
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| Sequence: | MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
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| BDBM50301297 |
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| n/a |
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| Name | BDBM50301297 |
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| Synonyms: | 2-benzyl-6,7,8,9-tetrahydro-2H-pyridazino[4,3-d]azepin-3(5H)-one | CHEMBL524778 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H17N3O |
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| Mol. Mass. | 255.315 |
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| SMILES | O=c1cc2CCNCCc2nn1Cc1ccccc1 |
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| Structure | 
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