| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol lipase-beta |
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| Ligand | BDBM434879 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1924060 (CHEMBL4427016) |
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| IC50 | 7.9±n/a nM |
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| Citation |  Janssen, FJ; van der Stelt, M Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders. Bioorg Med Chem Lett26:3831-7 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol lipase-beta |
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| Name: | Diacylglycerol lipase-beta |
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| Synonyms: | DGL-beta | DGLB_MOUSE | Daglb | Sn1-specific diacylglycerol lipase beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73906.34 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_101275 |
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| Residue: | 669 |
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| Sequence: | MPGMVLFGRRWSLASDDLVFPGSFELFLRVLWWIVSLTLYLTHRRRLDCPGGVLLSTYLI
VLLVLLAVIICTVLAIVCVSMRGTICNPGPRKSMSKLLYIRLALFLPEMVWASLGAAWVA
KGIQCDRTVVIGIIATVIVSWIVIAATMVTIIFVFDPLGGKMAPYPPCIPEHLDSNSSNR
LLTGLKTAAKSVWETRVQFCCCCVGQDDNTRVAFSSTADLFSTYFSDTDLVPSDIAAGFT
LLHQQQDNISHSREPPEVVTHTPGQPQETELDAEVENCHHYMPFAAAAYGWPLYIYRNPF
TGLCRIGGDCCRARDIEYDAVEGDQHNCHFASILKTTGLQYRDFIHISFHDKVYELPFIV
VLDHRKESVVVAVRGTMSLQDVLTDLSAESETLELGIELQDCVAHKGIAQAARYIHRRLV
NDGILSQAFSVAPEYQLVLVGHSLGAGAAALLAIMLRGAYPQVRAYAFSPPRGLLSKSLY
EYSKDFVVSLILGMDVIPRLSVTNMEDLKRRILRVIANCNKPKYKILLHGCWYGLFGGSP
DNFPTELDEGTQGALTQPLLGEQTLLTRYSPGYCSSDSPLDSPTKYPTLYPPGRIIHLEE
EGGSGRFGCCSAAQYRARWAHEAEFSKILIGPKMLIDHMPDVMIRALDRVLADRTACVSC
PGQGGSSVP
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| BDBM434879 |
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| n/a |
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| Name | BDBM434879 |
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| Synonyms: | US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazole-1-carbonyl)piperazine-1-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C26H28F3N5O4 |
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| Mol. Mass. | 531.5268 |
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| SMILES | CC(C)(C)OC(=O)N1CCN(C(Cc2ccccc2)C1)C(=O)n1cc(nn1)-c1ccc(OC(F)(F)F)cc1 |
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| Structure | 
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