| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol lipase-alpha |
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| Ligand | BDBM50519345 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1924062 (CHEMBL4427018) |
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| IC50 | 25±n/a nM |
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| Citation |  Janssen, FJ; van der Stelt, M Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders. Bioorg Med Chem Lett26:3831-7 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol lipase-alpha |
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| Name: | Diacylglycerol lipase-alpha |
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| Synonyms: | DGL-alpha | DGLA_MOUSE | Dagla | Kiaa0659 | Neural stem cell-derived dendrite regulator | Nsddr | Sn1-specific diacylglycerol lipase alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 115371.22 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_101098 |
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| Residue: | 1044 |
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| Sequence: | MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGR
GYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLT
QYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTY
NLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGL
VLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSHEMLRYKEVCYYMLFAL
AAYGWPMYLMRKPTCGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLD
ENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVE
GHRGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAI
LSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQ
LLDVLQRSTKPKWRIIVGATKCIPKSELPEDQVEVTTLASTRLWTHPSDLTIALSASTPL
YPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGL
NKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPLPTGLALELPATEHR
NSSVRSKSQSEMSLEGFSEGRLLSPVAAASAARQDPVELLLLSTQERLAAELQSRRAPLA
TMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRT
ELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSATIEEEEAAGGSEGGGVAPRGELALH
NGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMMVPESPTSDYTEGPKSPSQQEI
LLRAQFEPNLVPKPPRLFAGSAEPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLATDK
IRTSTPTGHGASPTKQDDLVISAR
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| BDBM50519345 |
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| n/a |
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| Name | BDBM50519345 |
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| Synonyms: | CHEMBL4447844 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24N2O2 |
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| Mol. Mass. | 384.4703 |
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| SMILES | Cc1ccc(cc1)-c1cnc2nc(oc2c1)C(=O)CCCCCc1ccccc1 |
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| Structure | 
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