| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 3 |
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| Ligand | BDBM50415550 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1924239 (CHEMBL4427195) |
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| IC50 | 2400±n/a nM |
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| Citation |  Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A New P2X3 receptor antagonists. Part 1: Discovery and optimization of tricyclic compounds. Bioorg Med Chem Lett26:3896-904 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 3 |
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| Name: | P2X purinoceptor 3 |
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| Synonyms: | ATP receptor | Glucocorticoid receptor | P2RX3 | P2RX3_HUMAN | P2X purinoceptor 3 | P2X purinoceptor 3 (P2RX3) | P2X purinoceptor 3 (P2X3) | P2X3 | P2X3 purinoceptor | Purinergic receptor | p2x3 + hsa |
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| Type: | Protein |
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| Mol. Mass.: | 44292.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P56373 |
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| Residue: | 397 |
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| Sequence: | MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDS
QCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEE
VNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
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| BDBM50415550 |
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| n/a |
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| Name | BDBM50415550 |
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| Synonyms: | CHEMBL599760 | Ro-85 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27N5O2S |
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| Mol. Mass. | 425.547 |
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| SMILES | C[C@H](CN1CCN(CC1)C(C)=O)NC(=O)c1cc2c(nn(C)c2s1)-c1ccccc1 |r| |
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| Structure | 
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