| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM50033680 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_41055 (CHEMBL648219) |
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| IC50 | 977000±n/a nM |
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| Citation |  Buynak, JD; Doppalapudi, VR; Rao, AS; Nidamarthy, SD; Adam, G The synthesis and evaluation of 2-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors. Bioorg Med Chem Lett10:847-51 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | BLAC_STAAU | Beta-lactamase TEM | Penicillinase | blaZ |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31367.53 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_41052 |
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| Residue: | 281 |
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| Sequence: | MKKLIFLIVIALVLSACNSNSSHAKELNDLEKKYNAHIGVYALDTKSGKEVKFNSDKRFA
YASTSKAINSAILLEQVPYNKLNKKVHINKDDIVAYSPILEKYVGKDITLKALIEASMTY
SDNTANNKIIKEIGGIKKVKQRLKELGDKVTNPVRYEIELNYYSPKSKKDTSTPAAFGKT
LNKLIANGKLSKENKKFLLDLMLNNKSGDTLIKDGVPKDYKVADKSGQAITYASRNDVAF
VYPKGQSEPIVLVIFTNKDNKSDKPNDKLISETAKSVMKEF
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| BDBM50033680 |
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| n/a |
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| Name | BDBM50033680 |
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| Synonyms: | CHEMBL268919 | Sodium; (R)-3-acetoxymethyl-7-[1-tert-butoxycarbonyl-meth-(Z)-ylidene]-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18NO9S |
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| Mol. Mass. | 400.381 |
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| SMILES | CC(=O)OCC1=C(N2[C@@H](\C(=C/C(=O)OC(C)(C)C)C2=O)S(=O)(=O)C1)C([O-])=O |t:5| |
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| Structure | 
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