| Reaction Details |
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 | Report a problem with these data |
| Target | Neuroendocrine convertase 2 |
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| Ligand | BDBM50533413 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1925258 (CHEMBL4428330) |
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| Ki | 0.360000±n/a nM |
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| Citation |  Kumar, R; Juillerat-Jeanneret, L; Golshayan, D Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases. J Med Chem59:7719-37 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuroendocrine convertase 2 |
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| Name: | Neuroendocrine convertase 2 |
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| Synonyms: | KEX2-like endoprotease 2 | NEC 2 | NEC2 | NEC2_HUMAN | Neuroendocrine convertase 2 | PC2 | PCSK2 | Prohormone convertase 2 | Proprotein convertase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 70563.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1290738 |
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| Residue: | 638 |
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| Sequence: | MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKL
PFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDIN
MNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASN
YNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRM
LDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGK
GSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRK
RNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRN
QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIP
STGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRP
RDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYI
DQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN
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| BDBM50533413 |
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| n/a |
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| Name | BDBM50533413 |
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| Synonyms: | CHEMBL3126388 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H66ClN11O5 |
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| Mol. Mass. | 744.412 |
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| SMILES | CCCCCCCCCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)CCl |r| |
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| Structure | 
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