| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H1 receptor |
|---|
| Ligand | BDBM50089146 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_83769 |
|---|
| IC50 | 26±n/a nM |
|---|
| Citation |  Upton, C; Osborne, RH; Jaffar, M Conformationally-restricted ligands for the histamine H1 receptor. Bioorg Med Chem Lett10:1277-9 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H1 receptor |
|---|
| Name: | Histamine H1 receptor |
|---|
| Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 55641.53 |
|---|
| Organism: | Cavia porcellus (domestic guinea pig) |
|---|
| Description: | Guinea pig cerebellum was used in binding assay. |
|---|
| Residue: | 488 |
|---|
| Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
|
|
|
|---|
| BDBM50089146 |
|---|
| n/a |
|---|
| Name | BDBM50089146 |
|---|
| Synonyms: | ((3R,4S)-4-Hydroxy-1-methyl-4-phenyl-piperidin-3-yl)-phenyl-methanone | CHEMBL23638 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H21NO2 |
|---|
| Mol. Mass. | 295.3755 |
|---|
| SMILES | CN1CC[C@](O)([C@@H](C1)C(=O)c1ccccc1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
