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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sterol O-acyltransferase 1 | ||
| Ligand | BDBM50089627 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_28943 | ||
| IC50 | 58±n/a nM | ||
| Citation |  Obata, R; Sunazuka, T; Otoguro, K; Tomoda, H; Harigaya, Y; Omura, S Synthetic conversion of ACAT inhibitor to acetylcholinesterase inhibitor. Bioorg Med Chem Lett10:1315-6 (2000) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sterol O-acyltransferase 1 | |||
| Name: | Sterol O-acyltransferase 1 | ||
| Synonyms: | ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT | ||
| Type: | Multi-pass membrane protein may form homo- or heterodimers. | ||
| Mol. Mass.: | 64751.94 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P35610 | ||
| Residue: | 550 | ||
| Sequence: |
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| BDBM50089627 | |||
| n/a | |||
| Name | BDBM50089627 | ||
| Synonyms: | 12-hydroxy-4,6a,12b-trimethyl-3,6-di(methylcarbonyloxy)-11-oxo-9-(3-pyridyl)-(3S,4R,6S,6aS,12R,12bS)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-4-ylmethyl acetate | Acetic acid 3-acetoxy-4-acetoxymethyl-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-pyridin-3-yl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-7,10-dioxa-benzo[a]anthracen-6-yl ester | CHEMBL25532 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H37NO10 | ||
| Mol. Mass. | 583.6262 | ||
| SMILES | CC(=O)OC[C@]1(C)[C@H](CC[C@@]2(C)C1C[C@H](OC(C)=O)[C@@]1(C)Oc3cc(oc(=O)c3[C@H](O)C21)-c1cccnc1)OC(C)=O | ||
| Structure | 
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