Reaction Details |
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Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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Ligand | BDBM50417153 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1927853 (CHEMBL4430925) |
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IC50 | 60±n/a nM |
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Citation | Armstrong, M; van Hoorebeke, C; Horn, T; Deschamps, J; Freedman, JC; Kalyanaraman, C; Jacobson, MP; Holman, T Human 15-LOX-1 active site mutations alter inhibitor binding and decrease potency. Bioorg Med Chem24:5380-5387 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polyunsaturated fatty acid lipoxygenase ALOX15 |
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Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
Synonyms: | 15-Lipoxygenase-1 (15-LOX-1) | ALOX15 | Arachidonate 15-lipoxygenase | Arachidonate 15-lipoxygenase-1 | LOG15 | LOX15_HUMAN | Reticulocyte 15-lipoxygenase-1 | Sphingosine 1-phosphate receptor 1 (S1P1) |
Type: | Protein |
Mol. Mass.: | 74804.05 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 662 |
Sequence: | MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI
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BDBM50417153 |
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n/a |
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Name | BDBM50417153 |
Synonyms: | CHEMBL1270704 |
Type | Small organic molecule |
Emp. Form. | C27H18N2O3S |
Mol. Mass. | 450.508 |
SMILES | O=C(OCC#CCSc1nnc(o1)-c1cccc2ccccc12)c1ccc2ccccc2c1 |
Structure |
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