Reaction Details |
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Target | Endothelin receptor type B |
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Ligand | BDBM50089712 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_64043 |
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IC50 | 24000±n/a nM |
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Citation | Zhang, J; Didierlaurent, S; Fortin, M; Lefrançois, D; Uridat, E; Vevert, JP Nonpeptide endothelin antagonists: from lower affinity pyrazol-5-ols to higher affinity pyrazole-5-carboxylic acids. Bioorg Med Chem Lett10:1351-5 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin receptor type B |
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Name: | Endothelin receptor type B |
Synonyms: | EDNRB_RAT | ENDOTHELIN B | ET-B | Ednrb | Endothelin receptor | Endothelin receptor non-selective type |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 49483.43 |
Organism: | RAT |
Description: | ENDOTHELIN B EDNRB RAT::P21451 |
Residue: | 442 |
Sequence: | MQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTKEVMTPPTKTSWTRGSN
SSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
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BDBM50089712 |
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n/a |
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Name | BDBM50089712 |
Synonyms: | 4-Benzo[1,3]dioxol-5-ylmethyl-2-benzyl-5-trifluoromethyl-2H-pyrazol-3-ol | CHEMBL3144845 |
Type | Small organic molecule |
Emp. Form. | C19H15F3N2O3 |
Mol. Mass. | 376.3292 |
SMILES | FC(F)(F)c1[nH]n(Cc2ccccc2)c(=O)c1Cc1ccc2OCOc2c1 |
Structure |
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