| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50089727 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_63354 |
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| IC50 | 5600±n/a nM |
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| Citation |  Zhang, J; Didierlaurent, S; Fortin, M; Lefrançois, D; Uridat, E; Vevert, JP Nonpeptide endothelin antagonists: from lower affinity pyrazol-5-ols to higher affinity pyrazole-5-carboxylic acids. Bioorg Med Chem Lett10:1351-5 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48256.91 |
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| Organism: | RAT |
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| Description: | ENDOTHELIN A EDNRA RAT::P26684 |
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| Residue: | 426 |
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| Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
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| BDBM50089727 |
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| n/a |
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| Name | BDBM50089727 |
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| Synonyms: | 2,4-Bis-benzo[1,3]dioxol-5-ylmethyl-5-trifluoromethyl-2H-pyrazol-3-ol | CHEMBL3144602 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15F3N2O5 |
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| Mol. Mass. | 420.3387 |
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| SMILES | FC(F)(F)c1[nH]n(Cc2ccc3OCOc3c2)c(=O)c1Cc1ccc2OCOc2c1 |
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| Structure | 
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