| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
|---|
| Ligand | BDBM50090102 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_145814 (CHEMBL753526) |
|---|
| Ki | 0.226±n/a nM |
|---|
| Citation |  Stevens, WC; Jones, RM; Subramanian, G; Metzger, TG; Ferguson, DM; Portoghese, PS Potent and selective indolomorphinan antagonists of the kappa-opioid receptor. J Med Chem43:2759-69 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Kappa-type opioid receptor |
|---|
| Name: | Kappa-type opioid receptor |
|---|
| Synonyms: | KOR-1 | Kappa Opioid Receptor | OPIATE Kappa | OPRK_RAT | Opioid receptor | Oprk1 | Ror-d |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 42692.90 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | P34975 |
|---|
| Residue: | 380 |
|---|
| Sequence: | MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRV
RNTVQDPASMRDVGGMNKPV
|
|
|
|---|
| BDBM50090102 |
|---|
| n/a |
|---|
| Name | BDBM50090102 |
|---|
| Synonyms: | 5'-N-Biguanidino-17-cyclopropylmethyl-6,7-didehydro-4,5alpha-epoxy-3,14-dihydroxyindolo[2',3':6,7]morphinan | CHEMBL92917 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H31N7O3 |
|---|
| Mol. Mass. | 513.5908 |
|---|
| SMILES | NC(=N)N=C(N)Nc1ccc2[nH]c3[C@@H]4Oc5c6c(CC7N(CC8CC8)CC[C@@]46[C@@]7(O)Cc3c2c1)ccc5O |w:3.2,TLB:15:16:28:20.26.25,34:17:28:20.26.25| |
|---|
| Structure | 
|
|---|
Search and Browse
