| Reaction Details |
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 | Report a problem with these data |
| Target | Synaptic vesicular amine transporter |
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| Ligand | BDBM50068436 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1929290 (CHEMBL4432466) |
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| Ki | 60±n/a nM |
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| Citation |  Nickell, JR; Culver, JP; Janganati, V; Zheng, G; Dwoskin, LP; Crooks, PA Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2. Bioorg Med Chem Lett26:4441-4445 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Synaptic vesicular amine transporter |
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| Name: | Synaptic vesicular amine transporter |
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| Synonyms: | Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2 |
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| Type: | Protein |
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| Mol. Mass.: | 55689.58 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q01827 |
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| Residue: | 515 |
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| Sequence: | MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEI
QTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPS
EDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFS
SSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFG
SVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAG
SICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWL
CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYG
SVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEK
MAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
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| BDBM50068436 |
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| n/a |
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| Name | BDBM50068436 |
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| Synonyms: | 1,4-Bis-[2-(3-methoxy-phenyl)-ethyl]-piperazine | CHEMBL146546 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H30N2O2 |
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| Mol. Mass. | 354.4858 |
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| SMILES | COc1cccc(CCN2CCN(CCc3cccc(OC)c3)CC2)c1 |
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| Structure | 
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