| Reaction Details |
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 | Report a problem with these data |
| Target | Cannabinoid receptor 1 |
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| Ligand | BDBM50534911 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1929482 (CHEMBL4432658) |
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| IC50 | 9.0±n/a nM |
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| Citation |  Greig, IR; Baillie, GL; Abdelrahman, M; Trembleau, L; Ross, RA Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators. Bioorg Med Chem Lett26:4403-4407 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cannabinoid receptor 1 |
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| Name: | Cannabinoid receptor 1 |
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| Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52868.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21554 |
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| Residue: | 472 |
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| Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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| BDBM50534911 |
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| n/a |
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| Name | BDBM50534911 |
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| Synonyms: | CHEMBL4454441 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15BrFN3O2S |
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| Mol. Mass. | 460.319 |
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| SMILES | Fc1ccc(cc1)-c1ccc(CNS(=O)(=O)c2cc3cc(Br)ccc3[nH]2)nc1 |
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| Structure | 
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