Reaction Details |
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Target | Prostaglandin G/H synthase 1 |
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Ligand | BDBM50090631 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_158586 |
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IC50 | 5280±n/a nM |
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Citation | Bosch, J; Roca, T; Catena, JL; Llorens, O; Pérez, JJ; Lagunas, C; Fernández, AG; Miquel, I; Fernández-Serrat, A; Farrerons, C Synthesis and biological evaluation of 1,3,4-triaryl-3-pyrrolin-2-ones, a new class of selective cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett10:1745-8 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin G/H synthase 1 |
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Name: | Prostaglandin G/H synthase 1 |
Synonyms: | COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_HUMAN | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase) |
Type: | Enzyme |
Mol. Mass.: | 68692.62 |
Organism: | Homo sapiens (Human) |
Description: | P23219 |
Residue: | 599 |
Sequence: | MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS
NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ
YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY
ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF
DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA
LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL
VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS
PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
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BDBM50090631 |
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n/a |
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Name | BDBM50090631 |
Synonyms: | 3-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-1-(4-methoxy-phenyl)-1,5-dihydro-pyrrol-2-one | CHEMBL49606 |
Type | Small organic molecule |
Emp. Form. | C24H20FNO4S |
Mol. Mass. | 437.483 |
SMILES | COc1ccc(cc1)N1CC(=C(C1=O)c1ccc(F)cc1)c1ccc(cc1)S(C)(=O)=O |c:11| |
Structure |
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