| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
|---|
| Ligand | BDBM50090633 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_158586 |
|---|
| IC50 | 2500±n/a nM |
|---|
| Citation |  Bosch, J; Roca, T; Catena, JL; Llorens, O; Pérez, JJ; Lagunas, C; Fernández, AG; Miquel, I; Fernández-Serrat, A; Farrerons, C Synthesis and biological evaluation of 1,3,4-triaryl-3-pyrrolin-2-ones, a new class of selective cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett10:1745-8 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin G/H synthase 1 |
|---|
| Name: | Prostaglandin G/H synthase 1 |
|---|
| Synonyms: | COX-1 | COX1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_HUMAN | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 68692.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P23219 |
|---|
| Residue: | 599 |
|---|
| Sequence: | MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS
NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ
YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY
ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF
DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA
LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL
VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS
PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
|
|
|
|---|
| BDBM50090633 |
|---|
| n/a |
|---|
| Name | BDBM50090633 |
|---|
| Synonyms: | 1-(4-Fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-3-(4-methoxy-phenyl)-1,5-dihydro-pyrrol-2-one | CHEMBL45886 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H20FNO4S |
|---|
| Mol. Mass. | 437.483 |
|---|
| SMILES | COc1ccc(cc1)C1=C(CN(C1=O)c1ccc(F)cc1)c1ccc(cc1)S(C)(=O)=O |t:9| |
|---|
| Structure | 
|
|---|
Search and Browse
