| Reaction Details |
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 | Report a problem with these data |
| Target | Ephrin type-A receptor 4 |
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| Ligand | BDBM50535195 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1929961 (CHEMBL4433137) |
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| Kd | 19±n/a nM |
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| Citation |  Olson, EJ; Lechtenberg, BC; Zhao, C; Rubio de la Torre, E; Lamberto, I; Riedl, SJ; Dawson, PE; Pasquale, EB Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability. ACS Med Chem Lett7:841-6 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ephrin type-A receptor 4 |
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| Name: | Ephrin type-A receptor 4 |
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| Synonyms: | EPHA4 | EPHA4_HUMAN | Ephrin receptor | Ephrin type-A receptor 4 | HEK8 | SEK | TYRO1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 109859.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586961 |
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| Residue: | 986 |
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| Sequence: | MAGIFYFALFSCLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIM
DEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKE
TFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKG
FYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEK
DVPKMYCGADGEWLVPIGNCLCNAGHEERSGECQACKIGYYKALSTDATCAKCPPHSYSV
WEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDI
SYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTKVSITDLLAHTNYTFEIWAVNGVS
KYNPNPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYE
KDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRII
GDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPF
TYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYT
DKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTV
IQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYT
TRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEG
YRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESSRPNT
ALLDPSSPEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHVNQEDLARIGITAIT
HQNKILSSVQAMRTQMQQMHGRMVPV
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| BDBM50535195 |
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| n/a |
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| Name | BDBM50535195 |
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| Synonyms: | CHEMBL4530593 |
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| Type | Small organic molecule |
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| Emp. Form. | C67H91N17O18S2 |
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| Mol. Mass. | 1486.673 |
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| SMILES | CC(C)[C@@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(O)=O)NC(=O)CCNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)CCN |r| |
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| Structure | 
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