| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA (8-3)-desaturase |
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| Ligand | BDBM50116708 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1929998 (CHEMBL4433174) |
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| IC50 | 29±n/a nM |
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| Citation |  Miyahisa, I; Suzuki, H; Mizukami, A; Tanaka, Y; Ono, M; Hixon, MS; Matsui, J T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time. ACS Med Chem Lett7:868-72 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA (8-3)-desaturase |
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| Name: | Acyl-CoA (8-3)-desaturase |
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| Synonyms: | FADS1 | FADS1_HUMAN | FADSD5 | Fatty acid desaturase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51985.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1513296 |
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| Residue: | 444 |
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| Sequence: | MAPDPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVIS
HYAGQDATDPFVAFHINKGLVKKYMNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVE
RMGLMKANHVFFLLYLLHILLLDGAAWLTLWVFGTSFLPFLLCAVLLSAVQAQAGWLQHD
FGHLSVFSTSKWNHLLHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPFFFA
LGKILSVELGKQKKKYMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVIQRKKWVDLAWMI
TFYVRFFLTYVPLLGLKAFLGLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNMDWVSTQL
QATCNVHKSAFNDWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKHGIEYQSKPLL
SAFADIIHSLKESGQLWLDAYLHQ
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| BDBM50116708 |
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| n/a |
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| Name | BDBM50116708 |
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| Synonyms: | CHEMBL2263368 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H11ClN2O |
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| Mol. Mass. | 246.692 |
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| SMILES | Nc1ccccc1C(=O)Nc1cccc(Cl)c1 |
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| Structure | 
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