| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA (8-3)-desaturase |
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| Ligand | BDBM50535222 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1929999 (CHEMBL4433175) |
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| IC50 | 2.1±n/a nM |
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| Citation |  Miyahisa, I; Suzuki, H; Mizukami, A; Tanaka, Y; Ono, M; Hixon, MS; Matsui, J T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time. ACS Med Chem Lett7:868-72 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA (8-3)-desaturase |
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| Name: | Acyl-CoA (8-3)-desaturase |
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| Synonyms: | FADS1_RAT | Fads1 | Fatty acid desaturase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52505.96 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_852948 |
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| Residue: | 447 |
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| Sequence: | MAPDPVQTPDPASAQLRQMRYFTWEEVAQRSGREKERWLVIDRKVYNISDFSRRHPGGSR
VISHYAGQDATDPFVAFHINKGLVRKYMNSLLIGELAPEQPSFEPTKNKALTDEFRELRA
TVERMGLMKANHLFFLFYLLHILLLDVAAWLTLWIFGTSLVPFTLCAVLLSTVQAQAGWL
QHDFGHLSVFSTSTWNHLVHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPL
FFALGKVLSVELGKEKKKHMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVVQRKKWVDLA
WMLSFYVRVFFTYMPLLGLKGLLCLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNVDWVS
TQLQATCNVHQSAFNNWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKYGIKYESK
PLLTAFADIVYSLKESGQLWLDAYLHQ
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| BDBM50535222 |
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| n/a |
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| Name | BDBM50535222 |
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| Synonyms: | CHEMBL4439992 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16F3N3O3S2 |
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| Mol. Mass. | 443.463 |
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| SMILES | CC(=O)NCCSc1nc2cscc2c(=O)n1-c1ccc(OCC(F)(F)F)cc1 |
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| Structure | 
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