Reaction Details |
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Target | Inosine-5'-monophosphate dehydrogenase |
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Ligand | BDBM50158460 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1930116 (CHEMBL4433367) |
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IC50 | 55000±n/a nM |
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Citation | Alexandre, T; Lupan, A; Helynck, O; Vichier-Guerre, S; Dugué, L; Gelin, M; Haouz, A; Labesse, G; Munier-Lehmann, H First-in-class allosteric inhibitors of bacterial IMPDHs. Eur J Med Chem167:124-132 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Inosine-5'-monophosphate dehydrogenase |
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Name: | Inosine-5'-monophosphate dehydrogenase |
Synonyms: | 1.1.1.205 | IMP dehydrogenase | IMPD | IMPDH | guaB |
Type: | PROTEIN |
Mol. Mass.: | 51707.42 |
Organism: | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Description: | ChEMBL_119670 |
Residue: | 489 |
Sequence: | MLRISQEALTFDDVLLIPGYSEVLPKDVSLKTRLTRGIELNIPLVSAAMDTVTEARLAIA
MAQEGGIGIIHKNMGIEQQAAEVRKVKKHETAIVRDPVTVTPSTKIIELLQMAREYGFSG
FPVVEQGELVGIVTGRDLRVKPNAGDTVAAIMTPKDKLVTAREGTPLEEMKAKLYENRIE
KMLVVDENFYLRGLVTFRDIEKAKTYPLASKDEQGRLRVGAAVGTGADTGERVAALVAAG
VDVVVVDTAHGHSKGVIERVRWVKQTFPDVQVIGGNIATAEAAKALAEAGADAVKVGIGP
GSICTTRIVAGVGVPQISAIANVAAALEGTGVPLIADGGIRFSGDLAKAMVAGAYCVMMG
SMFAGTEEAPGEIELFQGRSYKSYRGMGSLGAMSGSQGSSDRYFQDASAGAEKLVPEGIE
GRVPYKGALSAIVHQLMGGLRAAMGYTGSADIQQMRTQPQFVRITGAGMAESHVHDVQIT
KEAPNYRVG
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BDBM50158460 |
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n/a |
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Name | BDBM50158460 |
Synonyms: | (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone | 2-ethyl-3-(3,5-dibrom-4-hydroxybenzoyl)benzofuran | 3,5-dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone | Benzbromarone | CHEMBL388590 | US9725430, Compound 1 | US9856239, benzbromarone | US9962362, Compound 1 | Uroleap (TN) | cid_2333 |
Type | Small organic molecule |
Emp. Form. | C17H12Br2O3 |
Mol. Mass. | 424.083 |
SMILES | CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 |
Structure |
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