| Reaction Details |
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 | Report a problem with these data |
| Target | Atrial natriuretic peptide receptor 1 |
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| Ligand | BDBM50091761 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_34995 |
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| Ki | >10±n/a nM |
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| Citation |  Veale, CA; Alford, VC; Aharony, D; Banville, DL; Bialecki, RA; Brown, FJ; Damewood, JR; Dantzman, CL; Edwards, PD; Jacobs, RT; Mauger, RC; Murphy, MM; Palmer, W; Pine, KK; Rumsey, WL; Garcia-Davenport, LE; Shaw, A; Steelman, GB; Surian, JM; Vacek, EP The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg Med Chem Lett10:1949-52 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Atrial natriuretic peptide receptor 1 |
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| Name: | Atrial natriuretic peptide receptor 1 |
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| Synonyms: | ANP-A | ANPRA | ANPRA_HUMAN | Atrial natriuretic peptide A-type receptor | Atrial natriuretic peptide receptor | Atrial natriuretic peptide receptor A | GC-A | Guanylate cyclase | NPR-A | NPR1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 118919.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_700223 |
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| Residue: | 1061 |
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| Sequence: | MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVE
LALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVY
AAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWER
QALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGR
VIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDV
SARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLY
IQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAF
RVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGS
LSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNY
GSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVG
ACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGN
LKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAG
DVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLM
QRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLE
EKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTL
LNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFR
IRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSET
KAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
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| BDBM50091761 |
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| n/a |
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| Name | BDBM50091761 |
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| Synonyms: | (S)-N-[(S)-4-Guanidino-1-((S)-2-methyl-butylcarbamoyl)-butyl]-3-{(2S,3S)-2-[(S)-5-guanidino-2-(2-{4-[(naphthalene-2-carbonyl)-amino]-phenyl}-acetylamino)-pentanoylamino]-3-methyl-pentanoylamino}-succinamic acid | CHEMBL58588 |
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| Type | Small organic molecule |
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| Emp. Form. | C46H66N12O8 |
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| Mol. Mass. | 915.0918 |
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| SMILES | CC[C@H](C)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)Cc1ccc(NC(=O)c2ccc3ccccc3c2)cc1)[C@@H](C)CC |
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| Structure | 
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