| Reaction Details |
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 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily V member 2 |
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| Ligand | BDBM50535865 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1932438 (CHEMBL4478090) |
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| IC50 | 51900±n/a nM |
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| Citation |  De Petrocellis, L; Arroyo, FJ; Orlando, P; Schiano Moriello, A; Vitale, RM; Amodeo, P; Sánchez, A; Roncero, C; Bianchini, G; Martín, MA; López-Alvarado, P; Menéndez, JC Tetrahydroisoquinoline-Derived Urea and 2,5-Diketopiperazine Derivatives as Selective Antagonists of the Transient Receptor Potential Melastatin 8 (TRPM8) Channel Receptor and Antiprostate Cancer Agents. J Med Chem59:5661-83 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transient receptor potential cation channel subfamily V member 2 |
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| Name: | Transient receptor potential cation channel subfamily V member 2 |
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| Synonyms: | Sac2b | TRPV2_RAT | Transient receptor potential cation channel subfamily V member 2 | Trpv2 | Vanilloid receptor | Vrl1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 86707.60 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_768011 |
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| Residue: | 761 |
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| Sequence: | MTSASSPPAFRLETSDGDEEGNAEVNKGKQEPPPMESPFQREDRNSSPQIKVNLNFIKRP
PKNTSAPSQQEPDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTC
LMKAVLNLQDGVNACIMPLLQIDKDSGNPKLLVNAQCTDEFYQGHSALHIAIEKRSLQCV
KLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLE
ATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLK
LAAKEGKIEIFRHILQREFSGPYQPLSRKFTEWCYGPVRVSLYDLSSVDSWEKNSVLEII
AFHCKSPNRHRMVVLEPLNKLLQEKWDRLVSRFFFNFACYLVYMFIFTVVAYHQPSLDQP
AIPSSKATFGESMLLLGHILILLGGIYLLLGQLWYFWRRRLFIWISFMDSYFEILFLLQA
LLTVLSQVLRFMETEWYLPLLVLSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRF
LLVYLVFLFGFAVALVSLSREARSPKAPEDNNSTVTEQPTVGQEEEPAPYRSILDASLEL
FKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNHVADNSWSIW
KLQKAISVLEMENGYWWCRRKKHREGRLLKVGTRGDGTPDERWCFRVEEVNWAAWEKTLP
TLSEDPSGPGITGNKKNPTSKPGKNSASEEDHLPLQVLQSP
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| BDBM50535865 |
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| n/a |
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| Name | BDBM50535865 |
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| Synonyms: | CHEMBL4543647 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H36N2O5 |
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| Mol. Mass. | 564.6707 |
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| SMILES | COc1cc2CCN([C@@H](c3ccccc3)c2cc1OC)C(=O)N1CCc2cc(OC)c(OC)cc2[C@@H]1c1ccccc1 |r| |
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| Structure | 
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