| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase TAO2 |
|---|
| Ligand | BDBM50536344 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1933645 (CHEMBL4479297) |
|---|
| IC50 | 1000±n/a nM |
|---|
| Citation |  Piala, AT; Akella, R; Potts, MB; Dudics-Giagnocavo, SA; He, H; Wei, S; White, MA; Posner, BA; Goldsmith, EJ Discovery of novel TAOK2 inhibitor scaffolds from high-throughput screening. Bioorg Med Chem Lett26:3923-7 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase TAO2 |
|---|
| Name: | Serine/threonine-protein kinase TAO2 |
|---|
| Synonyms: | 2.7.11.1 | Serine/threonine-protein kinase TAO2 | TAOK2_RAT | Tao2 | Taok2 | Thousand and one amino acid protein 2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 138761.39 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_119215 |
|---|
| Residue: | 1235 |
|---|
| Sequence: | MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS
YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHK
KPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN
SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQN
ESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDA
VRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSIS
ASSQSSSVNSLADASDNEEEEEEEEEEEEEEEEEGPESREMAMMQEGEHTVTSHSSIIHR
LPGSDNLYDDPYQPEMTPGPLQPPAAPPTSTSSSSARRRAYCRNRDHFATIRTASLVSRQ
IQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSGRLQRELEAQRAGFGTE
AEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEEL
QENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLD
QDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQL
EYNKRREQELRQKHAAQVRQQPKSLKVRAGQLPMGLPATGALGPLSTGTLSEEQPCSSGQ
EAILGQRMLGEEEEAVPERMILGKEGTTLEPEEQRILGEEMGTFSSSPQKHRSLVNEEDW
DISKEMKESRVPSLASQERNIIGQEEAGAWNLWEKEHGNLVDMEFKLGWVQGPVLTPVPE
EEEEEEEEGGAPIGTPRDPGDGCPSPDIPPEPPPSHLRQYPASQLPGFLSHGLLTGLSFA
VGSSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLFLCTALHLPPSLFL
LLAQGTALGAVLSLSWRRGLMGVPLGLGAAWLLAWPSLALPLAAMAAGGKWVRQQGPQMR
RGISRLWLRVLLRLSPMVFRALQGCAAVGDRGLFALYPKTNKNGFRSRLPVPWPRQGNPR
TTQHPLALLARVWALCKGWNWRLARASHRLASCLPPWAVHILASWGLLKGERPSRIPRLL
PRSQRRLGLSASRQLPPGTVAGRRSQTRRALPPWR
|
|
|
|---|
| BDBM50536344 |
|---|
| n/a |
|---|
| Name | BDBM50536344 |
|---|
| Synonyms: | CHEMBL600947 | GNF-Pf-2911 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H13BrN4OS2 |
|---|
| Mol. Mass. | 409.324 |
|---|
| SMILES | CC(=O)Nc1nc(C)c(s1)-c1csc(Nc2ccc(Br)cc2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
