Reaction Details |
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Target | Histone-lysine N-methyltransferase SUV39H2 |
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Ligand | BDBM50009672 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1933906 (CHEMBL4479558) |
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IC50 | 22000±n/a nM |
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Citation | Spurr, SS; Bayle, ED; Yu, W; Li, F; Tempel, W; Vedadi, M; Schapira, M; Fish, PV New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms. Bioorg Med Chem Lett26:4518-4522 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone-lysine N-methyltransferase SUV39H2 |
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Name: | Histone-lysine N-methyltransferase SUV39H2 |
Synonyms: | H3-K9-HMTase 2 | Histone H3-K9 methyltransferase 2 | Histone-lysine N-methyltransferase SUV39H2 | Histone-lysine N-methyltransferase SUV39H2 (Suv39H2) | KMT1B | Lysine N-methyltransferase 1B | SUV39H2 | SUV92_HUMAN | Su(var)3-9 homolog 2 | Suppressor of variegation 3-9 homolog 2 |
Type: | Enzyme |
Mol. Mass.: | 46692.47 |
Organism: | Homo sapiens (Human) |
Description: | Q9H5I1 |
Residue: | 410 |
Sequence: | MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKD
MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK
PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG
ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP
NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK
GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR
TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN
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BDBM50009672 |
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n/a |
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Name | BDBM50009672 |
Synonyms: | AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocysteine | S-(5'-deoxyadenosin-5'-yl)-L-homocysteine | S-[1-(adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl]-L-homocysteine | S-adenosyl-L-homocysteine | SAH | US8895245, S-Adenosyl-L-homocysteine (SAH) | US9175331, 1 | US9333217, S-Adenosyl-L-homocysteine (SAH) |
Type | Small organic molecule |
Emp. Form. | C14H20N6O5S |
Mol. Mass. | 384.411 |
SMILES | N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |
Structure |
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