| Reaction Details |
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 | Report a problem with these data |
| Target | Calpain-1 catalytic subunit |
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| Ligand | BDBM50092302 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_139011 |
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| Ki | 810.0±n/a nM |
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| Citation |  Lubisch, W; Hofmann, HP; Treiber, HJ; Möller, A Synthesis and biological evaluation of novel piperidine carboxamide derived calpain inhibitors. Bioorg Med Chem Lett10:2187-91 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Calpain-1 catalytic subunit |
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| Name: | Calpain-1 catalytic subunit |
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| Synonyms: | CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1 |
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| Type: | Protein |
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| Mol. Mass.: | 81880.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 714 |
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| Sequence: | MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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| BDBM50092302 |
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| n/a |
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| Name | BDBM50092302 |
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| Synonyms: | 1-(Naphthalene-2-sulfonyl)-piperidine-4-carboxylic acid [1-benzyl-2-(3-morpholin-4-yl-propylcarbamoyl)-2-oxo-ethyl]-amide | CHEMBL69254 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H40N4O6S |
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| Mol. Mass. | 620.759 |
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| SMILES | O=C(NC(Cc1ccccc1)C(=O)C(=O)NCCCN1CCOCC1)C1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1 |
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| Structure | 
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