| Reaction Details |
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 | Report a problem with these data |
| Target | Calpain-1 catalytic subunit |
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| Ligand | BDBM50092304 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_139011 |
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| Ki | 13500±n/a nM |
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| Citation |  Lubisch, W; Hofmann, HP; Treiber, HJ; Möller, A Synthesis and biological evaluation of novel piperidine carboxamide derived calpain inhibitors. Bioorg Med Chem Lett10:2187-91 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Calpain-1 catalytic subunit |
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| Name: | Calpain-1 catalytic subunit |
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| Synonyms: | CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1 |
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| Type: | Protein |
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| Mol. Mass.: | 81880.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 714 |
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| Sequence: | MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEA
FPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHS
AEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILK
ALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGE
VEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
RTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFV
LALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSE
EEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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| BDBM50092304 |
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| n/a |
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| Name | BDBM50092304 |
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| Synonyms: | 1-((E)-3-Pyridin-4-yl-acryloyl)-piperidine-4-carboxylic acid (1-benzyl-2-carbamoyl-2-oxo-ethyl)-amide | CHEMBL306220 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N4O4 |
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| Mol. Mass. | 434.4876 |
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| SMILES | NC(=O)C(=O)C(Cc1ccccc1)NC(=O)C1CCN(CC1)C(=O)C=Cc1ccncc1 |w:25.27| |
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| Structure | 
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