Reaction Details |
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Target | Sodium- and chloride-dependent glycine transporter 2 |
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Ligand | BDBM50537049 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1935471 (CHEMBL4481230) |
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IC50 | 65±n/a nM |
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Citation | Mostyn, SN; Rawling, T; Mohammadi, S; Shimmon, S; Frangos, ZJ; Sarker, S; Yousuf, A; Vetter, I; Ryan, RM; Christie, MJ; Vandenberg, RJ Development of an N-Acyl Amino Acid That Selectively Inhibits the Glycine Transporter 2 To Produce Analgesia in a Rat Model of Chronic Pain. J Med Chem62:2466-2484 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium- and chloride-dependent glycine transporter 2 |
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Name: | Sodium- and chloride-dependent glycine transporter 2 |
Synonyms: | GLYT2 | Glycine transporter 2 | NET1 | SC6A5_HUMAN | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 87438.56 |
Organism: | Homo sapiens (Human) |
Description: | Glycine-2-transporter 0 HUMAN::Q9Y345 |
Residue: | 797 |
Sequence: | MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQ
TFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHC
KIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQ
EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA
GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFT
SQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGK
VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA
AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD
QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRT
HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQR
FCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWL
MLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTS
SLGLKLPVKDLELGTQC
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BDBM50537049 |
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n/a |
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Name | BDBM50537049 |
Synonyms: | CHEMBL4527071 |
Type | Small organic molecule |
Emp. Form. | C21H39NO4 |
Mol. Mass. | 369.5387 |
SMILES | CCCCCCCC\C=C/CCCCCCCC(=O)N[C@H](CO)C(O)=O |r| |
Structure |
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