| Reaction Details |
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 | Report a problem with these data |
| Target | Chymase |
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| Ligand | BDBM50093727 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_197657 |
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| IC50 | 550±n/a nM |
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| Citation |  Aoyama, Y; Uenaka, M; Konoike, T; Iso, Y; Nishitani, Y; Kanda, A; Naya, N; Nakajima, M 1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma. Bioorg Med Chem Lett10:2403-6 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Chymase |
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| Name: | Chymase |
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| Synonyms: | Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I |
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| Type: | Enzyme |
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| Mol. Mass.: | 27340.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 247 |
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| Sequence: | MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
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| BDBM50093727 |
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| n/a |
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| Name | BDBM50093727 |
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| Synonyms: | (6R,7R)-7-Methoxy-7-(2-methoxy-benzoylamino)-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester | (6R,7R)-7-Methoxy-7-(2-methoxy-benzoylamino)-3-(1-methyl-2,3-dihydro-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester | CHEMBL309201 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H30N6O7S |
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| Mol. Mass. | 642.682 |
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| SMILES | COc1ccccc1C(=O)N[C@@]1(OC)[C@H]2OCC(CSc3nnnn3C)=C(N2C1=O)C(=O)OC(c1ccccc1)c1ccccc1 |c:27| |
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| Structure | 
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