Reaction Details | |||
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Target | Endothelin receptor type B | ||
Ligand | BDBM50093978 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_64040 | ||
IC50 | 825±n/a nM | ||
Citation | Zhang, J; Didierlaurent, S; Fortin, M; Lefrançois, D; Uridat, E; Vevert, JP Potent nonpeptide endothelin antagonists: synthesis and structure-activity relationships of pyrazole-5-carboxylic acids. Bioorg Med Chem Lett10:2575-8 (2001) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Endothelin receptor type B | |||
Name: | Endothelin receptor type B | ||
Synonyms: | EDNRB_RAT | ENDOTHELIN B | ET-B | Ednrb | Endothelin receptor | Endothelin receptor non-selective type | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 49483.43 | ||
Organism: | RAT | ||
Description: | ENDOTHELIN B EDNRB RAT::P21451 | ||
Residue: | 442 | ||
Sequence: |
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BDBM50093978 | |||
n/a | |||
Name | BDBM50093978 | ||
Synonyms: | 2-(4-Carboxy-cyclohexylmethyl)-4-(6-chloro-benzo[1,3]dioxol-5-ylmethyl)-5-thiophen-2-yl-2H-pyrazole-3-carboxylic acid | CHEMBL86965 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H23ClN2O6S | ||
Mol. Mass. | 502.967 | ||
SMILES | OC(=O)C1CCC(Cn2nc(c(Cc3cc4OCOc4cc3Cl)c2C(O)=O)-c2cccs2)CC1 |(3.14,-11.22,;4.56,-11.81,;4.77,-13.34,;5.78,-10.87,;7.2,-11.46,;8.43,-10.52,;8.23,-8.98,;9.53,-8.16,;9.46,-6.62,;8.16,-5.78,;8.57,-4.28,;10.12,-4.21,;10.96,-2.92,;12.48,-2.92,;13.25,-4.24,;14.81,-4.24,;15.84,-5.36,;17.23,-4.73,;17.06,-3.21,;15.56,-2.9,;14.77,-1.57,;13.25,-1.59,;12.46,-.26,;10.66,-5.65,;12.15,-6.06,;12.55,-7.55,;13.25,-4.98,;7.67,-3.04,;8.15,-1.57,;6.9,-.65,;5.66,-1.57,;6.13,-3.04,;6.81,-8.41,;5.58,-9.35,)| | ||
Structure |