| Reaction Details |
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 | Report a problem with these data |
| Target | Thromboxane-A synthase |
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| Ligand | BDBM50006551 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_151518 (CHEMBL760420) |
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| IC50 | 150±n/a nM |
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| Citation |  Hartmann, RW; Hector, M; Wachall, BG; Palusczak, A; Palzer, M; Huch, V; Veith, M Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17). J Med Chem43:4437-45 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thromboxane-A synthase |
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| Name: | Thromboxane-A synthase |
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| Synonyms: | CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 60524.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24557 |
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| Residue: | 533 |
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| Sequence: | MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR
QGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV
ADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQR
CYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLA
RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV
RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN
PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV
LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL
GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
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| BDBM50006551 |
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| n/a |
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| Name | BDBM50006551 |
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| Synonyms: | (+)3-(4-Amino-phenyl)-3-cyclohexyl-piperidine-2,6-dione | (-)3-(4-Amino-phenyl)-3-cyclohexyl-piperidine-2,6-dione | 3-(4-Amino-phenyl)-3-cyclohexyl-piperidine-2,6-dione | CHEMBL70901 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H22N2O2 |
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| Mol. Mass. | 286.3688 |
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| SMILES | Nc1ccc(cc1)C1(CCC(=O)NC1=O)C1CCCCC1 |
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| Structure | 
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