Reaction Details |
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Target | Steroid 17-alpha-hydroxylase/17,20 lyase |
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Ligand | BDBM50094202 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_50374 (CHEMBL661717) |
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IC50 | >25000±n/a nM |
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Citation | Hartmann, RW; Hector, M; Wachall, BG; Palusczak, A; Palzer, M; Huch, V; Veith, M Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17). J Med Chem43:4437-45 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Steroid 17-alpha-hydroxylase/17,20 lyase |
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Name: | Steroid 17-alpha-hydroxylase/17,20 lyase |
Synonyms: | CP17A_RAT | Cyp17 | Cyp17a1 | Cytochrome P450 17,20 lyase | Cytochrome P450 17A1 | Cytochrome P450-C17 | Steroid 17-alpha-hydroxylase/17,20 lyase |
Type: | Enzyme |
Mol. Mass.: | 57255.68 |
Organism: | Rattus norvegicus (Rat) |
Description: | P11715 |
Residue: | 507 |
Sequence: | MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNFFKLQEKY
GPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSS
WHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVTNIICA
ICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPNKGLEVIKGYAKVRNE
VLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFG
AGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLMLEATIREVL
RIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPT
GSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPK
VVFLIDPFKVKITVRQAWMDAQAEVST
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BDBM50094202 |
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n/a |
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Name | BDBM50094202 |
Synonyms: | (R)-10,13-Dimethyl-17-oxiranyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one | (S)-10,13-Dimethyl-17-oxiranyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one | CHEMBL336902 |
Type | Small organic molecule |
Emp. Form. | C21H30O2 |
Mol. Mass. | 314.4617 |
SMILES | CC12CCC3C(CC=C4CC(=O)CCC34C)C1CCC2C1CO1 |t:7| |
Structure |
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