| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 3 |
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| Ligand | BDBM50056272 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_106387 (CHEMBL717242) |
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| EC50 | 62.8±n/a nM |
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| Citation |  Nakazato, A; Kumagai, T; Sakagami, K; Yoshikawa, R; Suzuki, Y; Chaki, S; Ito, H; Taguchi, T; Nakanishi, S; Okuyama, S Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists. J Med Chem43:4893-909 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 3 |
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| Name: | Metabotropic glutamate receptor 3 |
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| Synonyms: | GRM3_RAT | Gprc1c | Grm3 | Mglur3 | glutamate receptor, metabotropic 3 precursor |
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| Type: | Protein |
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| Mol. Mass.: | 98971.84 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P31422 |
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| Residue: | 879 |
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| Sequence: | MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRI
NEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVAS
DGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
AMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSY
LKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
VDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIK
HNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALL
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLP
EKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLH
LNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL
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| BDBM50056272 |
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| n/a |
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| Name | BDBM50056272 |
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| Synonyms: | (1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid | (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid | (2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid | 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid | 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY 354740) | 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid(LY354740) | CHEMBL8759 | LY-354740 | LY366563 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H11NO4 |
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| Mol. Mass. | 185.1772 |
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| SMILES | N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| |
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| Structure | 
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