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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Maternal embryonic leucine zipper kinase | ||
| Ligand | BDBM50538824 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1977283 (CHEMBL4610418) | ||
| Kd | 11±n/a nM | ||
| Citation |  Allegretti, PA; Horton, TM; Abdolazimi, Y; Moeller, HP; Yeh, B; Caffet, M; Michel, G; Smith, M; Annes, JP Generation of highly potent DYRK1A-dependent inducers of human ?-Cell replication via Multi-Dimensional compound optimization. Bioorg Med Chem28:0 (2020) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Maternal embryonic leucine zipper kinase | |||
| Name: | Maternal embryonic leucine zipper kinase | ||
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 74665.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14680 | ||
| Residue: | 651 | ||
| Sequence: |
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| BDBM50538824 | |||
| n/a | |||
| Name | BDBM50538824 | ||
| Synonyms: | CHEMBL4647416 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H30Cl2N4O3 | ||
| Mol. Mass. | 517.447 | ||
| SMILES | CCOC(=O)c1cnc2ccc(nc2c1N[C@H]1CC[C@H](CN(C)C)CC1)-c1cc(Cl)c(O)c(Cl)c1 |r,wU:16.17,wD:19.21,(38.56,-10.48,;37.23,-9.73,;35.9,-10.5,;34.57,-9.75,;34.56,-8.21,;33.24,-10.53,;33.25,-12.08,;31.92,-12.85,;30.58,-12.08,;29.24,-12.86,;27.92,-12.09,;27.92,-10.55,;29.24,-9.77,;30.58,-10.54,;31.9,-9.76,;31.9,-8.22,;30.56,-7.47,;29.23,-8.24,;27.9,-7.48,;27.89,-5.94,;26.55,-5.17,;26.54,-3.64,;25.2,-2.88,;27.87,-2.87,;29.21,-5.16,;30.55,-5.93,;26.59,-9.77,;26.59,-8.23,;25.26,-7.47,;25.26,-5.93,;23.92,-8.23,;22.58,-7.47,;23.93,-9.78,;22.59,-10.56,;25.26,-10.55,)| | ||
| Structure | 
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