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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Maternal embryonic leucine zipper kinase | ||
| Ligand | BDBM50538830 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1977283 (CHEMBL4610418) | ||
| Kd | 12±n/a nM | ||
| Citation |  Allegretti, PA; Horton, TM; Abdolazimi, Y; Moeller, HP; Yeh, B; Caffet, M; Michel, G; Smith, M; Annes, JP Generation of highly potent DYRK1A-dependent inducers of human ?-Cell replication via Multi-Dimensional compound optimization. Bioorg Med Chem28:0 (2020) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Maternal embryonic leucine zipper kinase | |||
| Name: | Maternal embryonic leucine zipper kinase | ||
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 74665.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14680 | ||
| Residue: | 651 | ||
| Sequence: |
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| BDBM50538830 | |||
| n/a | |||
| Name | BDBM50538830 | ||
| Synonyms: | CHEMBL4644916 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H35Cl2N5O2 | ||
| Mol. Mass. | 544.516 | ||
| SMILES | CCCCNC(=O)c1cnc2ccc(nc2c1N[C@H]1CC[C@H](CN(C)C)CC1)-c1cc(Cl)c(O)c(Cl)c1 |r,wU:18.19,wD:21.23,(87.72,-28.11,;86.39,-27.35,;85.07,-28.12,;83.74,-27.36,;82.41,-28.13,;81.07,-27.37,;81.06,-25.83,;79.74,-28.15,;79.75,-29.7,;78.42,-30.47,;77.08,-29.71,;75.75,-30.48,;74.42,-29.71,;74.42,-28.17,;75.74,-27.39,;77.08,-28.16,;78.41,-27.39,;78.4,-25.85,;77.06,-25.09,;75.73,-25.86,;74.4,-25.1,;74.39,-23.56,;73.05,-22.79,;73.04,-21.26,;71.7,-20.51,;74.37,-20.49,;75.71,-22.78,;77.05,-23.55,;73.09,-27.4,;73.09,-25.85,;71.76,-25.09,;71.76,-23.55,;70.42,-25.85,;69.09,-25.09,;70.43,-27.4,;69.1,-28.18,;71.76,-28.17,)| | ||
| Structure | 
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