| Reaction Details |
|---|
 | Report a problem with these data |
| Target | N-acylethanolamine-hydrolyzing acid amidase |
|---|
| Ligand | BDBM319796 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1977332 (CHEMBL4610467) |
|---|
| IC50 | 9.0±n/a nM |
|---|
| Citation |  Malamas, MS; Farah, SI; Lamani, M; Pelekoudas, DN; Perry, NT; Rajarshi, G; Miyabe, CY; Chandrashekhar, H; West, J; Pavlopoulos, S; Makriyannis, A Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors. Bioorg Med Chem28:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| N-acylethanolamine-hydrolyzing acid amidase |
|---|
| Name: | N-acylethanolamine-hydrolyzing acid amidase |
|---|
| Synonyms: | ASAH-like protein | Asahl | N-acylethanolamine acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase | N-acylethanolamine-hydrolyzing acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase subunit alpha | N-acylethanolamine-hydrolyzing acid amidase subunit beta | N-acylsphingosine amidohydrolase-like | NAAA_RAT | Naaa |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 40306.53 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | Q5KTC7 |
|---|
| Residue: | 362 |
|---|
| Sequence: | MGTPAIRAACHGAHLALALLLLLSLSDPWLWATAPGTPPLFNVSLDAAPELRWLPMLQHY
DPDFVRAAVAQVIGDRVPQWILEMIGEIVQKVESFLPQPFTSEIRGICDYLNLSLAEGVL
VNLAYEASAFCTSIVAQDSQGRIYHGRNLDYPFGNALRKLTADVQFVKNGQIVFTATTFV
GYVGLWTGQSPHKFTISGDERDKGWWWENMIAALSLGHSPISWLIRKTLTESEDFEAAVY
TLAKTPLIADVYYIVGGTSPQEGVVITRDRGGPADIWPLDPLNGAWFRVETNYDHWEPVP
KRDDRRTPAIKALNATGQAHLSLETLFQVLSVFPVYNNYTIYTTVMSAAEPDKYMTMIRN
PS
|
|
|
|---|
| BDBM319796 |
|---|
| n/a |
|---|
| Name | BDBM319796 |
|---|
| Synonyms: | US10174015, Compound 9 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H18ClNO3 |
|---|
| Mol. Mass. | 295.761 |
|---|
| SMILES | Clc1cccc(CCCCCC(=O)N2CCOC2=O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
