| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50095504 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_90549 (CHEMBL701899) |
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| IC50 | 250±n/a nM |
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| Citation |  Wai, JS; Egbertson, MS; Payne, LS; Fisher, TE; Embrey, MW; Tran, LO; Melamed, JY; Langford, HM; Guare, JP; Zhuang, L; Grey, VE; Vacca, JP; Holloway, MK; Naylor-Olsen, AM; Hazuda, DJ; Felock, PJ; Wolfe, AL; Stillmock, KA; Schleif, WA; Gabryelski, LJ; Young, SD 4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells. J Med Chem43:4923-6 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | Human immunodeficiency virus type 1 integrase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32231.48 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_90865 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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| BDBM50095504 |
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| n/a |
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| Name | BDBM50095504 |
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| Synonyms: | 4-[3-(3-Fluoro-benzyl)-phenyl]-2,4-dioxo-butyric acid | CHEMBL144727 | CHEMBL198000 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13FO4 |
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| Mol. Mass. | 300.2811 |
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| SMILES | OC(=O)C(=O)CC(=O)c1cccc(Cc2cccc(F)c2)c1 |
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| Structure | 
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