Reaction Details |
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Target | Bromodomain-containing protein 8 |
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Ligand | BDBM50539801 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1979364 (CHEMBL4612499) |
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Kd | <1.000000±n/a nM |
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Citation | Li, Y; Zhao, J; Gutgesell, LM; Shen, Z; Ratia, K; Dye, K; Dubrovskyi, O; Zhao, H; Huang, F; Tonetti, DA; Thatcher, GRJ; Xiong, R Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib. J Med Chem63:7186-7210 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bromodomain-containing protein 8 |
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Name: | Bromodomain-containing protein 8 |
Synonyms: | BRD8 | BRD8_HUMAN | Bromodomain-containing protein 8 | SMAP | SMAP | SMAP2 | Skeletal muscle abundant protein | Skeletal muscle abundant protein 2 | Thyroid hormone receptor coactivating protein of 120 kDa | TrCP120 | p120 |
Type: | PROTEIN |
Mol. Mass.: | 135233.03 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_109820 |
Residue: | 1235 |
Sequence: | MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVNESEMAVASGHLNSTGVLLEVGGVL
PMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTTVASEPPVKLVPPP
VESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGDPHTVTVSMDSSEI
SMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYTGEELDFETVGDII
AIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAPEMTV
KQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAGVVPATSMEPPELR
SQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPSHGSNPIEDPLEAE
TQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKEEDQGEGYLSEMDN
EPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVW
RAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMF
QNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQD
ASEKDSVPMGSPAFLLSLFMGHEWVWLDSEQDHPNDSELSNDCRSLFSSWDSSLDLDVGN
WRETEDPEAEELEESSPEREPSELLVGDGGSEESQEAARKASHQNLLHFLSEVAYLMEPL
CISSNESSEGCCPPSGTRQEGREIKASEGERELCRETEELSAKGDPLVAEKPLGENGKPE
VASAPSVICTVQGLLTESEEGEAQQESKGEDQGEVYVSEMEDQPPSGECDDAFNIKETPL
VDTLFSHATSSKLTDLSQDDPVQDHLLFKKTLLPVWKMIASHRFSSPFLKPVSERQAPGY
KDVVKRPMDLTSLKRNLSKGRIRTMAQFLRDLMLMFQNAVMYNDSDHHVYHMAVEMRQEV
LEQIQVLNIWLDKRKGSSSLEGEPANPVDDGKPVF
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BDBM50539801 |
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n/a |
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Name | BDBM50539801 |
Synonyms: | CHEMBL4648912 | US11840533, Compound 70 |
Type | Small organic molecule |
Emp. Form. | C30H28N6O3S |
Mol. Mass. | 552.647 |
SMILES | CCS(=O)(=O)Nc1cc(cc2n(ccc12)C(C)(c1ccccn1)c1ccccn1)-c1cn(C)c2c1cc[nH]c2=O |
Structure |
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